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Article

NBS1 variant I171V and breast cancer risk.

Breast cancer research and treatment - 1 Nov 2008

Bogdanova Natalia, Schürmann Peter, Waltes Regina, Feshchenko Sergei, Zalutsky Iosif Viktorovich, Bremer Michael, Dörk Thilo

Abstract excerpt

The NBS1/p95 protein has a pivotal role in the sensing and repair of chromosome breaks. A missense mutation in the NBS1 gene, I171V, has recently been associated with a ninefold increased risk of breast cancer in Polish patients. Positive associations have also been reported for leukaemia and larynx cancer suggesting that I171V could be a more general susceptibility factor for malignancies. We investigated the...

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PMID: 18049891
DOI: 10.1007/s10549-007-9820-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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NBS1 variant I171V and breast cancer risk.PMID 18049891Read ↗

Heterozygous carriers of the I171V mutation of the NBS1 gene have a significantly increased risk of solid malignant tumours.Semantic proximity Read ↗

I171V germline mutation in the NBS1 gene significantly increases risk of breast cancer.Semantic proximity Read ↗

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NBS1 657del5 mutation may contribute only to a limited fraction of breast cancer cases in Russia.Semantic proximity Read ↗

Functional variants in NBS1 and cancer risk: evidence from a meta-analysis of 60 publications with 111 individual studies.Semantic proximity Read ↗

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