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Article

Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury.

Transplantation - 27 Sept 2007

Riddle-Taylor Erica, Nagasaki Kazuhito, Lopez Joseph, Esquivel Carlos O, Martinez Olivia M, Krams Sheri M

Abstract excerpt

BACKGROUND: Apoptosis of hepatocytes contributes to many forms of liver pathology and can compromise liver function. Hepatocytes have been shown to require mitochondrial disruption to execute apoptosis, a process that is controlled by members of the Bcl-2 family. Bid is a proapoptotic Bcl-2 family member that is cleaved to its active form, tBid, by caspase 8 and granzyme B. Studies in the Bid-deficient mouse have...

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Identifiers

PMID: 17893612
DOI: 10.1097/01.tp.0000281555.18782.2b
PMCID: PMC4084732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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