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Article

BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts.

The Journal of biological chemistry - 21 Mar 2003

Sarig Rachel, Zaltsman Yehudit, Marcellus Richard C, Flavell Richard, Mak Tak W, Gross Atan

Abstract excerpt

The proapoptotic activity of BID seems to solely depend upon its cleavage to truncated tBID. Here we demonstrate that expression of a caspase-8 non-cleavable (nc) BID-D59A mutant or expression of wild type (wt) BID induces apoptosis in Bid -/-, caspase-8 -/-, and wt primary MEFs. Western blot analysis indicated that no cleavage products appeared in cells expressing ncBID. ncBID was as effective as wtBID in...

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Identifiers

PMID: 12519725
DOI: 10.1074/jbc.M210296200

Genes

BID

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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