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Article

BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals.

Cell death and differentiation - 1 Jun 2008

Jette C A, Flanagan A M, Ryan J, Pyati U J, Carbonneau S, Stewart R A, Langenau D M, Look A T, Letai A

Abstract excerpt

Here we investigate the function of zebrafish Bcl-2 family proteins and demonstrate important conservation of function across zebrafish and mammalian systems. We have isolated a zebrafish ortholog of mammalian BIM and show that it is the most toxic of the zebrafish BH3-only genes examined, sharing this characteristic with the mammalian BIM gene. The zebrafish bad gene shows a complete lack of embryonic lethality,...

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Identifiers

PMID: 18404156
DOI: 10.1038/cdd.2008.42
PMCID: PMC3212414

Genes

BID
BAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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