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Article

Defective FESTA/EAF2-mediated transcriptional activation in S-II-deficient embryonic stem cells.

Biochemical and biophysical research communications - 23 Nov 2007

Ito Takahiro, Saso Kayoko, Arimitsu Nagisa, Sekimizu Kazuhisa

Abstract excerpt

S-II is a transcription stimulation factor that enhances RNA synthesis by RNA polymerase II in vitro. To elucidate the function of S-II in transcriptional activation in mammalian cells, we generated an S-II-deficient murine embryonic stem (ES) cell line, DKO20, through targeted gene disruption. The DKO20 cells were viable, grew normally, and had a stable karyotype. The ability to evoke transcriptional activation...

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Source

Identifiers

PMID: 17892859
DOI: 10.1016/j.bbrc.2007.09.009

Genes

EAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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