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Article

Heterogeneity of epidermal growth factor receptor mutations within a mixed adenocarcinoma lung nodule.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2008

Nakano Hirofumi, Soda Hiroshi, Takasu Mineyo, Tomonaga Nanae, Yamaguchi Hiroyuki, Nakatomi Katsumi, Fujino Satoru, Hayashi Tomayoshi, Nakamura Yoichi, Tsukamoto Kazuhiro, Kohno Shigeru

Abstract excerpt

It has been proposed that stepwise progression occurs from atypical adenomatous hyperplasia (AAH) through bronchioloalveolar carcinoma (BAC) to invasive lung adenocarcinoma. However, the underlying molecular mechanisms have not been identified. We report a patient with a mixed adenocarcinoma of the lung that had different EGFR mutations in the papillary subtype, the acinar subtype, and the surrounding AAH and BAC...

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Source

Identifiers

PMID: 17889960
DOI: 10.1016/j.lungcan.2007.08.021

Genes

EGFR

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