Article
PTHR1 polymorphisms influence BMD variation through effects on the growing skeleton.
Calcified tissue international - 1 Oct 2007
Vilariño-Güell Carles, Miles Lisa J, Duncan Emma L, Ralston Stuart H, Compston Juliet E, Cooper Cyrus, Langdahl Bente L, Maclelland Alasdair, Pols Huibert A, Reid David M, Uitterlinden Andre G, Steer Colin D, Tobias Jon H, Wass John A, Brown Matthew A
Abstract excerpt
We investigated whether polymorphisms in PTHR1 are associated with bone mineral density (BMD), to determine whether the association of this gene with BMD was due to effects on attainment of peak bone mass or effects on subsequent bone loss. The PTHR1 gene, including its 14 exons, their exon-intron boundaries, and 1,500 bp of its promoter region, was screened for polymorphisms by denaturing high-performance liquid...
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