Article
A transgenic mouse model for high content, cell cycle phenotype screening in live primary cells.
Cell cycle (Georgetown, Tex.) - 15 Sept 2007
Burney Richard O, Lee Alan I, Leong Denise E, Jones Joshua T, Hahn Angela T, Meyer Tobias, Yao Mylene W M
Abstract excerpt
High content cell-based genetic and small molecule library screens are powerful strategies in drug discovery and investigations of disease mechanisms. We report that primary cells derived from a transgenic mouse model expressing a fluorescence mitosis biosensor provide unambiguous phenotype readouts without the need for transfection or immunocytochemistry. Phenotype profiles of cell cycle disruption and of...
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