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Article

Degradation of Nuclear Factor Kappa B during Foot-and-Mouth Disease Virus Infection

20 Sept 2007

Abstract excerpt

We have previously shown that the leader proteinase (L(pro)) of foot-and-mouth disease virus (FMDV) interferes with the innate immune response by blocking the translation of interferon (IFN) protein and by reducing the immediate-early induction of beta IFN mRNA and IFN-stimulated genes. Here, we report that L(pro) regulates the activity of nuclear factor kappaB (NF-kappaB). Analysis of NF-kappaB-dependent...

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PMID: 17881445
DOI: 10.1128/jvi.01467-07

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