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Article

Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease.

Journal of virology - 1 Feb 2012

Segundo Fayna Díaz-San, Weiss Marcelo, Pérez-Martín Eva, Dias Camila C, Grubman Marvin J, Santos Teresa de los

Abstract excerpt

Foot-and-mouth disease virus (FMDV) leader proteinase (L(pro)) cleaves itself from the viral polyprotein and cleaves the translation initiation factor eIF4G. As a result, host cell translation is inhibited, affecting the host innate immune response. We have demonstrated that L(pro) is also associated with degradation of nuclear factor κB (NF-κB), a process that requires L(pro) nuclear localization. Additionally,...

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Identifiers

PMID: 22114339
DOI: 10.1128/JVI.05941-11
PMCID: PMC3264347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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