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Inhibition of TNF‐α‐induced Activation of NF‐κB by Hantavirus Nucleocapsid Proteins

1 Sept 2009

Abstract excerpt

Hantaviruses cause two human diseases thought to be immune-mediated: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). We recently reported that the nucleocapsid (N) protein of HFRS-causing Hantaan virus (HTNV) inhibits tumor necrosis factor-alpha (TNF-alpha) activation of nuclear factor-kappaB (NF-kappaB). Here we measured the ability of other hantaviral N proteins to...

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PMID: 19751407
DOI: 10.1111/j.1749-6632.2009.05049.x

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