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Article

Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells.

Journal of virology - 1 Aug 2007

Mori Yoshio, Yamashita Tetsuo, Tanaka Yoshinori, Tsuda Yoshimi, Abe Takayuki, Moriishi Kohji, Matsuura Yoshiharu

Abstract excerpt

The flavivirus capsid protein not only is a component of nucleocapsids but also plays a role in viral replication. In this study, we found a small capsid protein in cells infected with Japanese encephalitis virus (JEV) but not in the viral particles. The small capsid protein was shown to be generated by processing with host cysteine protease cathepsin L. An in vitro cleavage assay revealed that cathepsin L...

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Source

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Identifiers

PMID: 17553875
DOI: 10.1128/JVI.00477-07
PMCID: PMC1951360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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