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Article

Organ-specific roles for transcription factor NF-κB in reovirus-induced apoptosis and disease

12 Aug 2005

Abstract excerpt

Reovirus induces apoptosis in cultured cells and in vivo. In cell culture models, apoptosis is contingent upon a mechanism involving reovirus-induced activation of transcription factor NF-kappaB complexes containing p50 and p65/RelA subunits. To explore the in vivo role of NF-kappaB in this process, we tested the capacity of reovirus to induce apoptosis in mice lacking a functional nfkb1/p50 gene. The genetic...

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PMID: 16100570
DOI: 10.1172/jci22428

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