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A rapid and sensitive bioassay to measure bone morphogenetic protein activity

19 Sept 2007

Abstract excerpt

BACKGROUND: Bone morphogenetic proteins (BMPs) are members of the TGF-beta superfamily and were originally identified as proteins that induce ectopic bone formation. BMPs were shown subsequently to be involved in several biological processes during development and in adult tissues through the regulation of the growth, differentiation and apoptosis of various cell types. An alkaline phosphatase (ALP)-based assay...

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PMID: 17880711
DOI: 10.1186/1471-2121-8-41

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