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Article

Gene therapy for bone formation: In vitro and in vivo osteogenic activity of an adenovirus expressing BMP7

1 Jan 2000

Abstract excerpt

Bone morphogenetic proteins (BMPs) are well-established agents for inducing orthotopic and ectopic bone formation. However, their clinical usefulness as regenerative agents may be limited by a short in vivo half-life and low specific activity. BMP gene therapy is an alternative route for exploiting the bone-inductive activity of this class of molecules. To test the feasibility of this approach, we examined the...

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PMID: 10861845
DOI: 10.1002/1097-4644(20000901)78:3<476::aid-jcb12>3.0.co;2-5

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