Article
Extensive apoptosis in lymphoid organs during primary SIV infection predicts rapid progression towards AIDS
1 Jul 2003
Abstract excerpt
OBJECTIVE: The acute phase of HIV and SIV infections leads to a host/virus equilibrium, and accumulating evidence suggests that this early phase dictates further progression towards AIDS. To gain insight into the early events that determine rapid disease progression, we performed a longitudinal study in the SIV rhesus macaque model, allowing an in-depth analysis of the primary stage of infection. METHODS: We...
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