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Article

Yeast screens show aromatic residues at the end of the sixth helix anchor transient receptor potential channel gate.

Proceedings of the National Academy of Sciences of the United States of America - 25 Sept 2007

Zhou Xinliang, Su Zhenwei, Anishkin Andriy, Haynes W John, Friske Eric M, Loukin Stephen H, Kung Ching, Saimi Yoshiro

Abstract excerpt

Transient receptor potential (TRP) channels are first elements in sensing chemicals, heat, and force and are widespread among protists and fungi as well as animals. Despite their importance, the arrangement and roles of the amino acids that constitute the TRP channel gate are unknown. The yeast TRPY1 is activated in vivo by osmotically induced vacuolar membrane deformation and by cytoplasmic Ca(2+). After a...

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Identifiers

PMID: 17878311
DOI: 10.1073/pnas.0704039104
PMCID: PMC2000494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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