Article
Yeast gain-of-function mutations reveal structure-function relationships conserved among different subfamilies of transient receptor potential channels.
Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2007
Su Zhenwei, Zhou Xinliang, Haynes W John, Loukin Stephen H, Anishkin Andriy, Saimi Yoshiro, Kung Ching
Abstract excerpt
Transient receptor potential (TRP) channels found in animals, protists, and fungi are primary chemo-, thermo-, or mechanosensors. Current research emphasizes the characteristics of individual channels in each animal TRP subfamily but not the mechanisms common across subfamilies. A forward genetic screen of the TrpY1, the yeast TRP channel, recovered gain-of-function (GOF) mutations with phenotype in vivo and in...
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