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Article

Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain.

Plant biology (Stuttgart, Germany) - 1 Sept 2016

Jaślan D, Mueller T D, Becker D, Schultz J, Cuin T A, Marten I, Dreyer I, Schönknecht G, Hedrich R

Abstract excerpt

The two-pore cation channel TPC1 operates as a dimeric channel in animal and plant endomembranes. Each subunit consists of two homologous Shaker-like halves, with 12 transmembrane domains in total (S1-S6, S7-S12). In plants, TPC1 channels reside in the vacuolar membrane, and upon voltage stimulation, give rise to the well-known slow-activating SV currents. Here, we combined bioinformatics, structure modelling,...

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PMID: 27270880
DOI: 10.1111/plb.12478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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