Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Construction and characterization of Bordetella pertussis mutants lacking the vir-regulated P.69 outer membrane protein.

Molecular microbiology - 1 Jun 1991

Roberts M, Fairweather N F, Leininger E, Pickard D, Hewlett E L, Robinson A, Hayward C, Dougan G, Charles I G

Abstract excerpt

The Bordetella pertussis P.69 protein is an immunogen with vaccine potential. The role of this protein in pathogenesis is unclear; it has been associated with the toxic adenylate cyclase and adhesion to eukaryotic cells. For further analysis of the role of P.69 in the biology of B. pertussis, we have constructed strains which specifically lack P.69. The cloned P.69 (prn) gene of B. pertussis was insertionally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Southern
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Line

Share to Mice, Inbred Strains

Share to Mutagenesis, Insertional

Share to Mutation

Share to Virulence

Source

Identifiers

PMID: 1787793
DOI: 10.1111/j.1365-2958.1991.tb00786.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Construction and characterization of Bordetella pertussis mutants lacking the vir-regulated P.69 outer membrane protein.PMID 1787793Read ↗

A new assay for invasion of HeLa 229 cells by Bordetella pertussis: effects of inhibitors, phenotypic modulation, and genetic alterations.Semantic proximity Read ↗

Polymorphism in the <i>Bordetella pertussis</i> Virulence Factors P.69/Pertactin and Pertussis Toxin in The Netherlands: Temporal Trends and Evidence for Vaccine-Driven EvolutionSemantic proximity Read ↗

The Bordetella pertussis virulence factor P.69 pertactin retains its immunological properties after overproduction in Escherichia coli.Semantic proximity Read ↗

A Novel Adhesin of <i>B. pertussis</i> is Key to Colonisation of Epithelial CellsSemantic proximity Read ↗

A phase variant of Bordetella pertussis with a mutation in a new locus involved in the regulation of pertussis toxin and adenylate cyclase toxin expression.Semantic proximity Read ↗

Construction of Bordetella pertussis strains that overproduce genetically inactivated pertussis toxin.Semantic proximity Read ↗

The proline residue at position 319 of BvgS is essential for BvgAS activation in Bordetella pertussis.Semantic proximity Read ↗

Characterization of mutant strains producing pertussis toxin cross reacting materials.Semantic proximity Read ↗

A vir-repressed gene of Bordetella pertussis is required for virulence.Semantic proximity Read ↗

Engineering of genetically detoxified pertussis toxin analogs for development of a recombinant whooping cough vaccine.Semantic proximity Read ↗

Mutations affecting the alpha subunit of Bordetella pertussis RNA polymerase suppress growth inhibition conferred by short C-terminal deletions of the response regulator BvgA.Semantic proximity Read ↗

Genetic and immunological studies on polypeptides encoded by the vir locus of Bordetella pertussis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.