Article
A phase variant of Bordetella pertussis with a mutation in a new locus involved in the regulation of pertussis toxin and adenylate cyclase toxin expression.
Journal of bacteriology - 1 Oct 1993
Carbonetti N H, Khelef N, Guiso N, Gross R
Abstract excerpt
A novel nonhemolytic phase variant of Bordetella pertussis was characterized. This strain is strongly impaired in the transcription of the pertussis and adenylate cyclase toxins, whereas other known virulence-related factors such as the filamentous hemagglutinin, the fimbriae, and the outer membr...
Topics
- Adenylate Cyclase Toxin
- Animals
- Antibodies, Bacterial
- Bordetella Infections
- Bordetella pertussis
- Gene Expression
- Gene Expression Regulation, Bacterial
- Genes, Regulator
- HeLa Cells
- Humans
- Mice
- Mutation
- Pertussis Toxin
- RNA, Messenger
- Respiratory Tract Infections