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A folylpoly-γ-glutamate synthase single nucleotide polymorphism associated with response to pemetrexed treatment combined with platinum for non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Dec 2016

Fukuda Satoshi, Oguri Tetsuya, Kunii Eiji, Sone Kazuki, Uemura Takehiro, Takakuwa Osamu, Maeno Ken, Kanemitsu Yoshihiro, Ohkubo Hirotsugu, Takemura Masaya, Ito Yutaka, Niimi Akio

Abstract excerpt

OBJECTIVES: In this study, we investigated whether single nucleotide polymorphisms (SNPs) in folylpoly-γ-glutamate synthase (FPGS), which catalyzes the polyglutamation of pemetrexed (PEM), is related to FPGS expression and the response to PEM in non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: We first examined FPGS protein expressions according to FPGS SNPs genotype groups in 15 lung adenocarcinoma...

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PMID: 27987582
DOI: 10.1016/j.lungcan.2016.10.006

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FPGS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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