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Article

Genetic variation in folylpolyglutamate synthase and gamma-glutamyl hydrolase and plasma homocysteine levels in the Singapore Chinese Health Study.

Molecular genetics and metabolism - 1 Jan 2012

Oppeneer Sarah J, Ross Julie A, Koh Woon-Puay, Yuan Jian-Min, Robien Kim

Abstract excerpt

The enzymes folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH) are essential for determining intracellular folate availability for one-carbon metabolism (OCM) pathways. FPGS adds glutamyl groups to the folate molecule, thereby converting folate into the preferred substrate for...

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Identifiers

PMID: 22018726
DOI: 10.1016/j.ymgme.2011.09.035
PMCID: PMC3253895

Genes

GGH
FPGS
OCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22018726-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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