Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis.

doi:10.1038/ncomms12111

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Article

Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis.

Nature communications - 20 Jul 2016

Banushi Blerida, Forneris Federico, Straatman-Iwanowska Anna, Strange Adam, Lyne Anne-Marie, Rogerson Clare, Burden Jemima J, Heywood Wendy E, Hanley Joanna, Doykov Ivan, Straatman Kornelis R, Smith Holly, Bem Danai, Kriston-Vizi Janos, Ariceta Gema, Risteli Maija, Wang Chunguang, Ardill Rosalyn E, Zaniew Marcin, Latka-Grot Julita, Waddington Simon N, Howe S J, Ferraro Francesco, Gjinovci Asllan, Lawrence Scott, Marsh Mark, Girolami Mark, Bozec Laurent, Mills Kevin, Gissen Paul

Abstract excerpt

Post-translational modifications are necessary for collagen precursor molecules (procollagens) to acquire final shape and function. However, the mechanism and contribution of collagen modifications that occur outside the endoplasmic reticulum and Golgi are not understood. We discovered that VIPAR, with its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newly identified...

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Identifiers

PMID: 27435297
DOI: 10.1038/ncomms12111
PMCID: PMC4961739

Genes

PLOD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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