Article
Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains.
Antimicrobial agents and chemotherapy - 1 Jul 2008
Laohavaleeson Somvadee, Tessier Pamela R, Nicolau David P
Abstract excerpt
Ceftobiprole (BPR) is an investigational cephalosporin with activity against Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA) strains. The pharmacodynamic (PD) profile of BPR against S. aureus strains with a variety of susceptibility phenotypes in an immunocompromised murine pneumonia model was characterized. The BPR MICs of the test isolates ranged from 0.25 to 2 mug/ml. Pharmacokinetic...
Topics
- Animals
- Anti-Bacterial Agents
- Cephalosporins
- Community-Acquired Infections
- Cross Infection
- Disease Models, Animal
- Drug Resistance, Bacterial
- Female
- Humans
- Methicillin Resistance
- Mice
- Mice, Inbred BALB C
- Phenotype
- Pneumonia, Staphylococcal