Article
Development of a non-invasive murine infection model for acute otitis media.
Microbiology (Reading, England) - 1 Dec 2009
Stol K, van Selm S, van den Berg S, Bootsma H J, Blokx W A M, Graamans K, Tonnaer E L G M, Hermans P W M
Abstract excerpt
Otitis media (OM) is one of the most frequent diseases in childhood, and Streptococcus pneumoniae is among the main causative bacterial agents. Since current experimental models used to study the bacterial pathogenesis of OM have several limitations, such as the invasiveness of the experimental procedures, we developed a non-invasive murine OM model. In our model, adapted from a previously developed rat OM model,...
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