Article
Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2001
Schultz M J, Wijnholds J, Peppelenbosch M P, Vervoordeldonk M J, Speelman P, van Deventer S J, Borst P, van der Poll T
Abstract excerpt
Leukotrienes (LTs) are considered important for antibacterial defense in the lung. Multidrug resistance protein 1 (mrp1) is a transmembrane protein responsible for the cellular extrusion of LTC(4). To determine the role of mrp1 in host defense against pneumonia, mrp1(-/-) and wild-type mice were intranasally inoculated with Streptococcus pneumoniae. mrp1(-/-) mice displayed a diminished outgrowth of pneumococci...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Female
- Genetic Predisposition to Disease
- Immunity, Innate
- Indoles
- Inflammation
- Injections, Intraperitoneal
- Intracellular Fluid
- Leukotriene B4
- Lipoxygenase Inhibitors
- Lung