Article
In vitro infection model characterizing the effect of efflux pump inhibition on prevention of resistance to levofloxacin and ciprofloxacin in Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Nov 2007
Louie Arnold, Brown David L, Liu Weiguo, Kulawy Robert W, Deziel Mark R, Drusano George L
Abstract excerpt
The prevalence of fluoroquinolone-resistant Streptococcus pneumoniae is slowly rising as a consequence of the increased use of fluoroquinolone antibiotics to treat community-acquired pneumonia. We tested the hypothesis that increased efflux pump (EP) expression by S. pneumoniae may facilitate the emergence of fluoroquinolone resistance. By using an in vitro pharmacodynamic infection system, a wild-type S....
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Biological Transport
- Ciprofloxacin
- DNA, Bacterial
- Drug Resistance, Bacterial
- Drug Resistance, Multiple
- Ethidium
- Fluoroquinolones
- Levofloxacin
- Microbial Sensitivity Tests
- Mutation
- Ofloxacin