Article
[Role of mutations on the "hepatitis B virus 'a' determinant hotpoint" to the efficacy of hepatitis B vaccine].
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi - 1 Apr 2007
Zhang Rui, Li Rong-cheng, Zhu Feng-cai, Li Yan-ping, Liu She-lan, Zhang Xian-chen, Wang Sheng-qi, Liang Zheng-lun, Li He-min, Zhuang Hui
Abstract excerpt
OBJECTIVE: To study how hepatitis B virus(HBV) 'a' determinant hotpoint mutations were influecing the hepatitis B vaccine efficacy. METHODS: Primers were designed in HBV conservative region, and the degenerate probes for detecting 16 'a' determinant hotpoint mutations were developed for gene chip...
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