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Combined UGT1A1 and UGT1A7 variant alleles are associated with increased risk of Gilbert's syndrome in Taiwanese adults.

Clinical genetics - 1 Oct 2007

Teng H-C, Huang M-J, Tang K-S, Yang S-S, Tseng C-S, Huang C-S

Abstract excerpt

Gilbert's syndrome (GS) is caused by a reduction in the activity of hepatic bilirubin UDP-glucuronosyltransferase (UGT). This reduction is associated with UGT1A1*28 and UGT1A1*6 polymorphisms. Recent research also showed that carriage of UGT1A1*6 allele were significantly related with UGT1A7*3. Polymerase chain reaction-restriction fragment length polymorphism were utilized to determine UGT1A7 and UGT1A1 genes...

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Gilbert Disease
Glucuronosyltransferase
Haplotypes
Linkage Disequilibrium
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17850628
DOI: 10.1111/j.1399-0004.2007.00873.x

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