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[Molecular Mechanism of Protein C Deficiency Caused by Mutations of PROC Gene N355S, G392E, T314A].

Zhongguo shi yan xue ye xue za zhi - 1 Dec 2024

Li Tian-Yi, Jiang Miao, Huang Lu-Lu, Han Jing-Jing, Ma Zhen-Ni, Bai Xia, Xia Li-Jun

Abstract excerpt

OBJECTIVE: To study the molecular mechanism of functional defect of protein C (PC) caused by point mutations of human protein C gene (PROC ) N355S , G392E and T314A. METHODS: The wild-type and mutant plasmids (PCWT, PCN355S, PCG392E, PCT314A) of PROC gene were constructed and transiently transfected into HEK293 cells. The expression of mutant proteins in vitro were tested. The mRNA level changes of wild-type and...

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PMID: 39743273
DOI: 10.19746/j.cnki.issn.1009-2137.2024.06.030

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