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Article

The high affinity calcium-binding site involved in protein C activation is outside the first epidermal growth factor homology domain.

The Journal of biological chemistry - 15 Jun 1992

Rezaie A R, Esmon N L, Esmon C T

Abstract excerpt

Binding Ca2+ to a high affinity site in protein C and 4-carboxyglutamic acid (Gla)-domainless protein C results in a conformational change that is required for activation by the thrombin-thrombomodulin complex, the natural activator of protein C. It has been hypothesized that this high affinity Ca(2+)-binding site is located in the NH2-terminal epidermal growth factor (EGF) homology region of protein C. We have...

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Identifiers

PMID: 1601845

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The high affinity calcium-binding site involved in protein C activation is outside the first epidermal growth factor homology domain.PMID 1601845Read ↗

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Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation.Semantic proximity Read ↗

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