Article

Dynamin-2 Mutations Linked to Neonatal-onset Centronuclear Myopathy impair exocytosis and endocytosis in adrenal chromaffin cells

2024-03-12

Abstract excerpt

<h4> ABSTRACT </h4> Dynamins are large GTPases whose primary function is to catalyze membrane scission during endocytosis, but also modulate other cellular processes, such as actin polymerization and vesicle trafficking. Recently, we reported that centronuclear myopathy associated dynamin-2 mutations, p.A618T and p.S619L, impair Ca 2+ -induced exocytosis of GLUT4 containing vesicles in immortalized human myobla...

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Literature Corpus work: 2269475f-bdda-5abc-957c-9db452a68c0a
DOI: 10.1101/2024.03.07.583689

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