Article
Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis.
Carcinogenesis - 1 May 2013
Kasaikina Marina V, Turanov Anton A, Avanesov Andrei, Schweizer Ulrich, Seeher Sandra, Bronson Roderick T, Novoselov Sergey N, Carlson Bradley A, Hatfield Dolph L, Gladyshev Vadim N
Abstract excerpt
Selenium (Se) has long been known for its cancer prevention properties, but the molecular basis remains unclear. The principal questions in assessing the effect of dietary Se in cancer are whether selenoproteins, small molecule selenocompounds, or both, are involved, and under which conditions and genotypes Se may be protective. In this study, we examined diethylnitrosamine-induced hepatocarcinogenesis in mice...
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