Article

Bayesian coalescent inference of in-host evolution using Next Generation Sequencing

2018-09-04

Abstract excerpt

Within an infected individual, influenza virus exists as a heterogeneous population of variants. When representing the viral population as a consensus sequence, information about minority variants is lost. However, using next generation sequencing (NGS), it is possible to identify nucleotide substitutions which segregate at low frequencies in the viral population, and can give insight into the within-host processe...

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Literature Corpus work: 54c50ae1-9d31-597a-b61a-99dedfaa1036
DOI: 10.1101/407965

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