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Article

Potent Antimalarial Activity of Acriflavine <i>In Vitro</i> and <i>In Vivo</i>

4 Aug 2014

Abstract excerpt

Malaria continues to be a major health problem globally. There is an urgent need to find new antimalarials. Acriflavine (ACF) is known as an antibacterial agent and more recently as an anticancer agent. Here, we report that ACF inhibits the growth of asexual stages of both chloroquine (CQ) sensitive and resistant strains of human malarial parasite, Plasmodium falciparum in vitro at nanomolar concentration. ACF...

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PMID: 25089658
DOI: 10.1021/cb500476q

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