Genomic organization and chromosomal localization of the human CTP synthetase gene (CTPS).

doi:10.1016/0888-7543(91)90036-e

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Article

Genomic organization and chromosomal localization of the human CTP synthetase gene (CTPS).

Genomics - 1 Dec 1991

Yamauchi M, Yamauchi N, Phear G, Spurr N K, Martinsson T, Weith A, Meuth M

Abstract excerpt

To elucidate the organization of the human genomic sequences encoding CTP synthetase (CTPS), fragments homologous to the cDNA were isolated from genomic lambda libraries. The fragments cloned were overlapping and cover over 40 kb. Cotransfection of the DNAs into CTPS-deficient, cytidine-requiring CHO mutants can transform them to cytidine-independent growth, indicating that the complete structural gene has been...

Topics

Animals
Base Sequence
Blotting, Southern
CHO Cells
Carbon-Nitrogen Ligases
Cell Division
Chromosome Mapping
Chromosomes, Human, Pair 1
Cloning, Molecular
Cricetinae
Cytidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA

Exons

Genes

Genetic Complementation Test

Humans

Introns

Ligases

Source

Open in PubMed

Identifiers

PMID: 1783378
DOI: 10.1016/0888-7543(91)90036-e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1783378-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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