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Article

Malignant phenotype of PC3 cell line was inhibited by siRNA targeting PAR gene.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban - 1 Aug 2007

Xu Xiaofeng, Zhou Siwei, Zhang Zhengyu, Ge Jingping, Cheng Wen, Wei Zhifeng, Zhang Xu, Gao Jianping

Abstract excerpt

To investigate the effects of down-regulation of prostate androgen regulated (PAR) expression on proliferation of PC3 cells by using RNA interference (RNAi), suppression of PAR expression was achieved by transfection of PC3 cells with short hairpin RNA (shRNA) expression vectors against PAR, designated as psiRNA-PAR1, psiRNA-PAR2 and psiRNA-PAR3. The inhibitory effects were confirmed by RT-PCR. The growth...

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PMID: 17828506
DOI: 10.1007/s11596-007-0423-4

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