Article
Genome-wide significance and replication of the chromosome 12p11.22 locus near the PTHLH gene for peripartum cardiomyopathy.
Circulation. Cardiovascular genetics - 1 Aug 2011
Horne Benjamin D, Rasmusson Kismet D, Alharethi Rami, Budge Deborah, Brunisholz Kimberly D, Metz Torri, Carlquist John F, Connolly Jennifer J, Porter T Flint, Lappé Donald L, Muhlestein Joseph B, Silver Robert, Stehlik Josef, Park James J, May Heidi T, Bair Tami L, Anderson Jeffrey L, Renlund Dale G, Kfoury Abdallah G
Abstract excerpt
BACKGROUND: Peripartum (PP) cardiomyopathy (CM) is a rare condition of unknown etiology that occurs in late pregnancy or early postpartum. Initial evidence suggests that genetic factors may influence PPCM. This study evaluated and replicated genome-wide association of single nucleotide polymorphisms with PPCM. METHODS AND RESULTS: Genome-wide single nucleotide polymorphisms in women with verified PPCM diagnosis...
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