Article
Ninjurin 1 asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage.
Journal of neuroimmunology - 1 Oct 2007
Cardoso Cynthia Chester, Martinez Alejandra Nóbrega, Guimarães Pedro Edson Moreira, Mendes Camila Teixeira, Pacheco Antônio Guilherme, de Oliveira Rosane Barbosa, Teles Rosane Magda Brandão, Illarramendi Ximena, Sampaio Elizabeth Pereira, Sarno Euzenir Nunes, Dias-Neto Emmanuel, Moraes Milton Ozório
Abstract excerpt
Leprosy is the major cause of non-traumatic neuropathy. Herein, we investigated the role of ninjurin 1, an adhesion molecule involved in nerve regeneration in leprosy. Our results demonstrated that M. leprae stimulates in vitro up-regulation of ninjurin mRNA in cultured Schwann and blood cells as well as in vivo mRNA and protein expression in leprosy nerve biopsies. A polymorphism (asp110ala) was investigated in...
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