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Cytotoxic T-lymphocyte antigen-4 polymorphisms and susceptibility to osteosarcoma.

DNA and cell biology - 1 Dec 2011

Liu Yang, He Zhimin, Feng Dapeng, Shi Guodong, Gao Rui, Wu Xiaodong, Song Weiguo, Yuan Wen

Abstract excerpt

Despite the knowledge of many genetic alterations present in osteosarcoma, the complexity of this disease precludes placing its biology into a simple conceptual framework. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays important roles in downregulating T-cell activation, thereby attenuating anti-tumor responses and increasing cancer susceptibility. Polymorphisms in the CTLA-4 gene are associated with different...

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PMID: 21612409
DOI: 10.1089/dna.2011.1269

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