Article
Monitoring of lipid storage in Caenorhabditis elegans using coherent anti-Stokes Raman scattering (CARS) microscopy.
Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2007
Hellerer Thomas, Axäng Claes, Brackmann Christian, Hillertz Per, Pilon Marc, Enejder Annika
Abstract excerpt
Better understanding of the fundamental mechanisms behind metabolic diseases requires methods to monitor lipid stores on single-cell level in vivo. We have used Caenorhabditis elegans as a model organism to demonstrate the limitations of fluorescence microscopy for imaging of lipids compared with coherent anti-Stokes Raman scattering (CARS) microscopy, the latter allowing chemically specific and label-free...
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