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Article

Induction and regulation of reversible suspended animation in C. elegans.

Nature communications - 31 Mar 2026

Liu Junqiang, Wang Bingying, Leon Catrow Jonathan, Pearce Quentinn, Ji Zhijian, Yang Supeng Winnie, Balakrishnan Akash, Cox James E, Ma Dengke K

Abstract excerpt

Suspended animation, a state of profound metabolic, behavioral and developmental quiescence, is a remarkable yet poorly understood stress resilience strategy in animals. Here, we describe a previously uncharacterized form of suspended animation inducible by high-population density in isosmotic liquids in C. elegans throughout larval development and adulthood. Transcriptomic, metabolomic, and live-cell activity...

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Identifiers

PMID: 41916978
DOI: 10.1038/s41467-026-71247-9
PMCID: PMC13199508

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