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Article

Tissue-Specific Consequences of Cyclin D1 Overexpression in Prostate Cancer Progression

1 Sept 2007

Abstract excerpt

The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G(1) to S phase of the cell cycle. Several prostate cancer cell lines and a subset of primary prostate cancer samples have increased cyclin D1 protein expression. However, the relationship between cyclin D1 expression and prostate tumor progression has yet to be...

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PMID: 17804732
DOI: 10.1158/0008-5472.can-07-0418

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