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Article

Role for Stromal Heterogeneity in Prostate Tumorigenesis

28 Mar 2011

Abstract excerpt

Prostate cancer develops through a stochastic mechanism whereby precancerous lesions on occasion progress to multifocal adenocarcinoma. Analysis of human benign and cancer prostate tissues revealed heterogeneous loss of TGF-β signaling in the cancer-associated stromal fibroblastic cell compartment. To test the hypothesis that prostate cancer progression is dependent on the heterogeneous TGF-β responsive...

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PMID: 21444670
DOI: 10.1158/0008-5472.can-10-2999

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