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Article

PIK3CA mutations frequently coexist with EGFR/KRAS mutations in non-small cell lung cancer and suggest poor prognosis in EGFR/KRAS wildtype subgroup.

PloS one - 1 Jan 2014

Wang Lei, Hu Haichuan, Pan Yunjian, Wang Rui, Li Yuan, Shen Lei, Yu Yongfu, Li Hang, Cai Deng, Sun Yihua, Chen Haiquan

Abstract excerpt

PURPOSE: PIK3CA gene encoding a catalytic subunit of the phosphatidylinositol-3-kinase (PI3K) is mutated and/or amplified in various neoplasia, including lung cancer. Here we investigated PIK3CA gene alterations, the expression of core components of PI3K pathway, and evaluated their clinical importance in non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Oncogenic mutations/rearrangements in PIK3CA,...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24533074
DOI: 10.1371/journal.pone.0088291
PMCID: PMC3922761

Genes

EGFR
KRAS
AKT1
ALK
BRAF
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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