Article
Association and linkage studies of the 20q11.2 region (GRD-2 locus) with Graves' disease in the Tunisian population.
Annals of human biology - 1 Jan 2000
Makni K, Hadj Kacem H, Rebaï A, Abid M, Ayadi H
Abstract excerpt
OBJECTIVE: A genome-wide screen has shown linkage to the GRD-2 locus in Graves' disease (GD). Furthermore, a positional candidate gene maps to this locus; the CD40 gene has been reported to be associated and may predispose to the disease. The aim of this study was to replicate/reject the GRD-2 and to determine if the single nucleotide polymorphism (SNP) of the CD40 (CD40 C/T-1) confers susceptibility to GD....
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