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Article

Role of the CD40 locus in Graves' disease.

Thyroid : official journal of the American Thyroid Association - 1 Jul 2004

Houston Fiona A, Wilson Valerie, Jennings Claire E, Owen Catherine J, Donaldson Peter, Perros Petros, Pearce Simon H S

Abstract excerpt

The genetic basis for Graves' disease remains largely unknown, but significant linkage to microsatellite markers on 20q11 suggests that this region harbors a susceptibility gene. One obvious candidate gene at this 20q11 locus is CD40, which encodes a B-cell-surface receptor that is involved in T-cell to B-cell signaling and is implicated in control of T-cell autoreactivity. In addition, an allele of a single...

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Source

Identifiers

PMID: 15307939
DOI: 10.1089/1050725041517039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the CD40 locus in Graves' disease.PMID 15307939Read ↗

A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease.Semantic proximity Read ↗

A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians.Semantic proximity Read ↗

A C/T polymorphism in the 5'-untranslated region of the CD40 gene is associated with Graves' disease in Koreans.Semantic proximity Read ↗

A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression.Semantic proximity Read ↗

Association of a C/T single-nucleotide polymorphism in the 5' untranslated region of the CD40 gene with Graves' disease in Japanese.Semantic proximity Read ↗

The genetics of Graves' disease.Semantic proximity Read ↗

Compelling Evidence Linking CD40 Gene With Graves' Disease in the Chinese Han Population.Semantic proximity Read ↗

Association and linkage studies of the 20q11.2 region (GRD-2 locus) with Graves' disease in the Tunisian population.Semantic proximity Read ↗

Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease.Semantic proximity Read ↗

A C/T polymorphism in the 5' untranslated region of the CD40 gene is associated with later onset of Graves' disease in Japanese.Semantic proximity Read ↗

Genetics of Graves' disease: the lost concept.Semantic proximity Read ↗

Association of single nucleotide polymorphism in CD28(C/T-I3 + 17) and CD40 (C/T-1) genes with the Graves' disease.Semantic proximity Read ↗

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