Article
CHFR gene is neither mutated nor hypermethylated in ovarian cancer.
Cancer detection and prevention - 1 Jan 2007
Ludwig Agnieszka H, Bujko Mateusz, Bidzinski Mariusz, Kupryjańczyk Jolanta
Abstract excerpt
BACKGROUND: CHFR is a mitotic checkpoint protein that under mitotic stress (caused also by taxanes) delays progression into mitosis. METHODS: We looked for CHFR gene (605,209) alterations and its promoter hypermethylation in 48 ovarian carcinomas either sensitive or resistant to taxane treatment. We used single-strand conformation polymorphism analysis, sequencing and methylation-specific polymerase chain...
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