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Article

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

Nature genetics - 1 Oct 2007

Menzel Stephan, Garner Chad, Gut Ivo, Matsuda Fumihiko, Yamaguchi Masao, Heath Simon, Foglio Mario, Zelenika Diana, Boland Anne, Rooks Helen, Best Steve, Spector Tim D, Farrall Martin, Lathrop Mark, Thein Swee Lay

Abstract excerpt

F cells measure the presence of fetal hemoglobin, a heritable quantitative trait in adults that accounts for substantial phenotypic diversity of sickle cell disease and beta thalassemia. We applied a genome-wide association mapping strategy to individuals with contrasting extreme trait values and mapped a new F cell quantitative trait locus to BCL11A, which encodes a zinc-finger protein, on chromosome 2p15. The...

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Identifiers

PMID: 17767159
DOI: 10.1038/ng2108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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